In trichology is clearly important for drugs that open potassium channels, which play a unique role in various medical fields: the miopreservazione and vasodilation in patients with heart disease and vascular disorders of bronchodilation, the muscle relaxant bladder control and even urinary incontinence, of antiepileptic drugs, control of hormonal secretion of pancreatic beta-cells (control of diabetes type 2) and hypothalamus, and stimulate the anagen phase of hair follicles preventing baldness .
Among the different therapeutic actions of drugs that open potassium channels, Jahangir (2005) shows the ability of minoxidil to stimulate hair growth by referring to its ability to prolong the anagen phase.
is absolutely known that minoxidil sulfate (the meta-bolic active) results in muscle relaxation of blood vessels (via opening of K + channels) resulting in vasodilation.
It is not clear the mechanism of action of vasodilation in the skin, and above all it is not clear why the 5% topical minoxidil is able to increase blood flow perifollicular, whereas this does not occur at lower concentrations. Randall Farjo
and have demonstrated the presence of two different gene expression of receptors 6.the Kir Kir 6.2 to the level of the papilla and the dermal matrix of the hair bulb. The potassium channels (KATP).
This study has shown conclusively that the dermal papilla and the matrix of the bulb containing the potassium channel, and therefore the action of minoxidil is directed to these ionic structures.
's opening of potassium channels, increases the anagen phase of the bulb in vitro, as well as the closure of channels by tolbutamide (a sulfonylurea used as hypoglycemic, which blocks potassium channels) gives the shortening dell'anagen in bulbs. vitro.
The effect of tolbutamide is also expressed in vivo, so that a side effect of this drug is fall hair, so that its topical use was patented in 2007 for the treatment of hypertrichosis.
But what is open potassium channels in hair follicles? The
minoxidil in vitro results in a significant increase in the synthesis of DNA in cells of the dermal papilla and matrix.
's opening of potassium channels stimulates cellular energy, inducing and maintaining the active phase of the hair bulb, and play a key role as a messenger that can stimulate the growth of new bulbs.
In practice, the minoxidil. acting on the channel directly stimulates the cells of the dermal papilla and matrix increasing protection DNA, and especially to keep alive the structure of the bulb.
L 'lengthening of the anagen phase, then, is the result of stimulation of cell activity. ALSO
Logical 'minooxidil stimuli that most bulbs in the anagen phase gives the initial, as it is logical that the stimulation of cell activity is causing a bulb in the anagen phase terminal, a progression of catagen and telogen until the trigger 'activities of the next anagen phase.
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